Nanocatalysis and Drug Molecules Lab
Research in our group is focused on developing new and elegant catalytic reactions that are highly efficient and of broad utility. This combines techniques of catalysis and organic synthesis for the development of synthetically important and environmental friendly catalytic transformations. Furthermore, we are also interested in the application of these novel reactions to the build various organic molecules for their potential application in medicinal chemistry as well as in materials science.
The research area of our group encompasses:
(A) Metal Catalyzed C-H Activation
We are interested in C-H activation, particularly in the development of novel catalytic methodologies for multiple C-H (sp2, sp3) functionalization, which can be applicable for the synthesis of biologically active natural products. Our primary target is to deliver the efficient protocol for the chemo and regio-selective C-C, C-O and C-N bond forming reactions to develop heterocyclic scaffolds, with the understanding of mechanistic details.
(B) Metal Catalyzed C-H functionalization / Defunctionalization
In general directing group (DG) assist C-H functionalization with an ease. However, further functionalization and reusability of DG is challenging task. Thus, our interest is to create alternative strategies for oxidative functionalization of inactivated sp2 and sp3 carbon hydrogen to carbon-carbon and carbon-heteroatom bond with a reusability of directing group. We are also interested to address challenges of chemo, regio and stereoselective C-H oxidations
The removal of functional groups from organic molecules is immensely important in synthesis of natural products and in biological processes. Synthetically, the utility of functional groups is mainly due to their ability to act as directing groups as well as high reactivity and selectivity in a wide variety of transformations. In this context, metal mediated defunctionalization has attracted attention of chemists for decades since such processes enable temporary use of the beneficial features of functional groups.
(C) Metal Catalyzed Reactions of Alkynes
1. Activation of Alkynes
The most fundamental reactivity pattern in metal-catalyzed organic reactions is the activation of a C–C multiple bonds, in most cases an alkyne, for the attack of a nucleophile. Cationic metal species coordinate to alkyne to form a reactive metal alkyne complex which can be undergoes various transformations and product precursor can be further utilized for building synthetically important compounds.
2. Lewis Acid Catalyzed Organic Transformations
Lewis acid known to catalyze various complicated organic transformations with the ease. We are interested in developing new and intermolecular mode of organic reactions catalyzed by lewis acids with the atom efficiency. Research plans are envisaged keeping in view the application of either of following concepts:
i) In-situ carbenoid ganaration
ii) Carbene/Nitrene Insertion
Related publications: Chem. Commu.., 2012, 48, 7200-7202.
Org. Lett. 2017, 19, 190