Research Interests and Activities In the context of systems biology, most of the biological events are the results of complex chemical reaction networks, and they are mainly regulated via two antagonistic feedback mechanisms: positive feedback and negative feedback. Living systems operate under out-of-equilibrium. The complex cellular reaction networks under the out-of-equilibrium environment produce complex nonlinear functions such as bistability, oscillation, or even chaotic behavior, which play key roles in cellular machinery. Cellular memory is also bistable in nature. Moreover, biological systems maintain homeostasis through such complex reaction networks and feedback mechanisms. Therefore, understanding the synthetic feedback-controlled reaction networks will provide a minimalist platform to understand the cellular reaction networks and machinery. Now the biggest question is, "How can we benefit from living technology?" Therefore, we are interested in understanding such complex natural functions elaborately by using synthetic complex chemical reaction networks. Further, our research group focuses on incorporating animate features in soft materials to open a new opportunity in the next-generation materials sciences. Therefore, we are interested in solving the existing problems in bioorganic chemistry,biological chemistry, systems chemistry, and soft functional material science. The specific research objective of our group is the following:
- Peptide and protein chemistry
- Synthetic self-replicating systems
- Engineering complex chemical reaction networks and autocatalytic reactions (proteins, peptides, DNA, enzymes, and small organic molecules)
- Engineering bistable and oscillation reaction networks in a flow reactor
- Molecular and supramolecular machines
- Functional soft materials, sensing platform, and targeted drug delivery
|
|
