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Research Activities
    • in the thematic area of cancer
    • in the thematic area of diabetes
    • in the thematic area of tuberculosis
    • in the thematic area of drug resistance
    • in other interdisciplinary thematic areas
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Research Activities: Dr. Amit Kumar Tyagi

Research in other interdisciplinary thematic areas

Our group is also interested in other areas of research such as biological interactions and environmental remediation studies. The core molecules focussed for such studied are organic compounds and few metal based compounds. Some of our works which have been published in these areas are given below-

Title: Enthalpy-driven interaction between dihydropyrimidine compound and bovine serum albumin: A spectroscopic and computational approach, Journal of Biomolecular Structure and Dynamics, 2018, 36, 1161-1170.

Authors: Manasa Kongot, Neha Maurya, Neeraj Dohare, Meharj Parray, Jitendra Kumar, Amit Kumar, Rajan Patel.

Highlights:

  • Synthesised and structurally characterised a bioactive dihydropyrimidine compound called EMOP (ethyl, 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate).
  • The interactive profile of EMOP with a model protein BSA was studied thoroughly using fluorescence, UV-Visible, time resolved fluorescence and Circular dichroism measurements.
  • Molecular docking and simulation studies were also performed to understand the interactions of EMOP with BSA.
  • Static quenching of BSA was observed and the binding was quite strong with an exothermic and spontaneous nature.
  • The experimental and MD simulation studies together suggested conformational changes in BSA on binding with EMOP.

Title: Removal of pentachlorophenol pesticide from aqueous solutions using modified chitosan, Arabian Journal of Chemistry, 2018, in press

Authors: Aparajita Shankar*, Manasa Kongot*, Vipin K. Saini, Amit Kumar, [*Authors have contributed equally]

Highlights:

  • Chitosan was modified and grafted to produce two new materials, one with a Schiff base linked chitosan CHTA and another a copper grafted material CHTAC.
  • The materials were characterised using techniques like SEM, EDAX, BET, ATIR techniques.
  • The potentiality of using these materials as bio adsorbents was studied by performing adsorption and desorption experiments of pentachlorophenol pesticide using the materials.
  • All the materials were found to be chemically unaltered with adsorption and desorption and a physical adsorption phenomenon was in action.
  • All the materials were tested for their reusability as adsorbents for 3 consecutive adsorption desorption cycles.
  • CHTA material showed about 94% adsorption capacity of PCP and this was higher than the pure chitosan material.

Title: An expeditious green cascade synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives via 'solvent drop grinding' and their Antioxidant and DNA protective studies, Chemistry Select, 2016, 1, 1723-1728

Authors: Sahana Kuntikana, Chinmay Bhat, Manasa Kongot, Subrahmanya Ishwar Bhat, Amit Kumar

Highlights:

  • Green method of grinding was used to synthesize quinazolinone type of compounds.
  • 38 examples were reported using the solvent assisted grinding method.
  • The reactions were catalyst free, involved simple grinding, minimal solvent, quicker and cleaner.
  • The products were structurally characterised using spectroscopic techniques and few selected compounds were studied for their antioxidant activity.
  • DPPH assay and DNA cleavage activity studies suggested significant antioxidant activity of the compounds.

 
       
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